In the previous article, I explained what is host throttling and what are the mitigation strategies to avoid reaching throttling condition.
Since Publishing throttling state = 4, we increased the process memory threshold, but this led to another problem. The host instance started generating an "out of memory" error. Microsoft recommends that if an "out of memory" error is raised by increasing the Process memory usage threshold, then consider reducing the values for the Internal message queue size and In-process messages per CPU thresholds. And in worse case, if your BizTalk server regularly runs out of virtual memory, then consider BizTalk Server 64-bit.